The formation, structure and properties of biofilms on hard tissue surfaces are studied extensively. The action of anticariogenic and antimicrobial agents are studied in the Constant Depth Film Fermenter (CDFF) and in a microtiter biofilm model.
Fluoride that, at present, is still the most effective caries-preventive agent is subject for further study. A better understanding of its mode of action, also on the molecular level towards microbial metabolism, as well as its possible side-effects (fluorosis and the induction of a fluoride-resistant oral microflora) will help to improve formulations and the development of fluoride-releasing devices and restorative materials.
In addition to fluoride, antimicrobials have come into focus as caries preventive agents. The efficacy alone or in combination with fluoride is still unknown and application protocols are not yet based on a critical evaluation of experimental and clinical results. The successes of antimicrobials in caries prevention are still limited.
- Cate, prof.dr. J.M., ten
- Crielaard, prof.dr. W.
- Loveren, prof.dr. C. van
- Soet, dr. J.J. de
- Strijp, dr. A.J.P. van
- Zaura, dr. E.