Klein Nulend, J.

+31 20 59 80881
acta ( mondgezondh )
Professor (Oral Cell Biology)


  • Growth
  • Mechanical adaptation
  • Regeneration of bone

Professional interests

  • Bone molecular biology
  • Bone biology
  • Bone mechanotransduction

Professional employment history

2009-presentFull Professor (Faculty Professor), ACTA-VU, Dept Oral Cell Biology, Amsterdam, NL. Chair founded by ACTA at the VU University Amsterdam.
2007-presentDirectorate Board member of the Research Institute MOVE.
2005-2009Full Professor (“Bijzonder Hoogleraar”), ACTA-VU, Dept Oral Cell Biology, Amsterdam, NL.  Chair founded by the Skeletal Tissue Engineering Group Amsterdam (STEGA).
2000-2005Associate professor, ACTA-VU, Dept Oral Cell Biology, Amsterdam, NL
1995-2000Assistant professor, ACTA-VU, Dept Oral Cell Biology, Amsterdam, NL.
1991-1995Research fellow at ACTA-VU, Oral Cell Biology, Amsterdam, NL.
1990-1991Research Fellow in Medicine, Massachusetts General Hospital and Harvard Medical School, Endocrine Unit, Boston, MA, USA.
1990-1995Fellow of the Royal Netherlands Academy of Arts and Sciences (KNAW).

Selected scientific publications

Juffer P, Jaspers RT, Lips P, Bakker AD, Klein-Nulend J: Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes. American Journal of Physiology – Endocrinology and Metabolism 302:E389-E395, 2012.
Kamioka H, Kameo Y, Imai Y, Bakker AD, Bacabac RG, Yamada N, Takaoka A, Yamashiro T, Adachi T, Klein-Nulend J: Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model. Integrative Biology (Cambridge) 4:1198-1206, 2012.
Farré-Guasch E, Prins HJ, Overman JR, Ten Bruggenkate CM, Schulten EA, Helder MN, Klein-Nulend J: Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one-step surgical procedures. Tissue Engineering Part B Reviews 19:69-82, 2013.
Van Dijk FS, Zillikens MC, Micha D, Riessland M, Marcelis CLM, de Die-Smulders CE, Milbradt J, Franken AAM, Harsevoort GJ, Lichtenbelt KD, Pruijs JE, Rubio-Gozalbo ME, Zwertbroek R, Moutaouakil Y, Egthuijsen J, Hammerschmidt M, Bijman R, Semeins CM, Bakker AD, Everts V, Klein-Nulend J, Campos-Obando N, Hofman A, Verkerk AJMH, Uitterlinden AG, Maugeri A, Sistermans EA, Waisfisz Q, Meijers-Heijboer H, Wirth B, Simon MEH, Pals G: X-linked PLS3 mutations cause osteoporosis and fractures. New England Journal of Medicine 369:1529-1536, 2013.
Klein-Nulend J, van Oers RF, Bakker AD, Bacabac RG: Nitric oxide signaling in mechanical adaptation of bone. Osteoporosis International 25:1427-1437, 2014.

LIST OF PUBLICATIONS (from 1999 until now)

Ancillary activities

Last changes Ancillary activities: Amsterdam 27 januari 2017