Research at the VUmc location

The research is focused on three research lines:

  • oral cancer and salivary gland tumours;
  • surgical orthopedics in the oral cavity;
  • reconstructive preprosthetic surgery and maxillofacial implantology.
Oral cancer and salivary gland tumours
A substantial percentage of oral cancer is preceded by so-called precursor lesions, particularly leukoplakia. Intervention in the precursor stage may prevent the development of frank malignancy. The ongoing intervention study of oral leukoplakia is being continued both in a retrospective and prospective manner. Amongst others, the prognostic value of the DNA content is examined with regard to the predictive value of malignant transformation. Salivary gland tumours are a very heterogeneous group of tumours, with more than 40 subtypes recognised in the most recent WHO classification. Classification is based solely on histopathology. Sometimes, correct classification and prediction of biological behaviour is difficult. Therefore, the studies aim to better characterize these tumours at the genomic and protein level.

Surgical orthopedics in the oral cavity
The research on surgical orthopedics is focused on maxillofacial function and healing capacity after treatment of acquired and congenital jaw deformities. Attention is focused on the indications/contra-indications and preventive measures in surgical-orthodontic treatment of dentofacial deformities. In addition, the dynamics of the surrounding tissues after corrective surgery of maxillofacial bones is studied. 

Reconstructive preprosthetic surgery and maxillofacial implantology
The research on maxillofacial implantology and reconstructive preprosthetic surgery deals primarily with bone and bone-substitutes in maxillofacial implantology. Research includes a number of investigations on the maxillary sinus floor elevation model, where bone grafts and bone substitutes are investigated.

Tenured staff

All scientific publications (from 2009 until now) for Oral and Maxillofacial Surgery VUmc